Urban digitalisation is currently drawing extensive attention on the socioeconomic performance in the high-frequency cities and its spatial logics for improving the spatiotemporal effectiveness of spatial interventions that are proposed. In the past decades, configurational analysis provided an ideology/methodology of decoding urban form and its relation to various functionality, which has been widely adopted in the urban studies and planning and design practice in the West. As a mainstream of configurational studies, space syntax delivered a novel way to model the spatial configuration and demonstrated a series of robust relationships between spatial centralities and urban performance. However, as a descriptive model, traditional space syntax model can hardly be used in planning and design processes to address temporal social issues that are emerging temporally. Based on space syntax model, this paper introduces a new method to quantify the spatiotemporal centralities of the spatial configuration, which is sensed via the urban flow data. The delivered method is called co-presence intensity, a dynamic concept in space syntax, to measure various geometric centralities and the emergent modes of humans’trajectories constrained by the spatial configuration. The findings in this paper demonstrate a trend to a dynamic, temporal, flow-focused configurational research from a static, aggregated, form-focused space syntax analysis. This work also implies that urban design, empowered by the proposed configurational analysis technology, can be considered as a social instrument for improving urban spatial functionality during a much short time period than before. This article ends with a discussion about how space syntax could be reconstructed in the new digital society facilitated by the new data environment.